During the last 4 decades there has been a dramatic improvement in the outcome of children with cancer. From an incurable disease, 8 of 10 children with cancer are cured today. The price of the cure, however, is significant due to the toxic effects of chemotherapy. We are now at the beginning of the new revolution of therapy for children with cancer.

The challenge to cure every child with cancer with more precise and less toxic drugs is attainable and depends on the translation of the dramatic progress in genomic and biological research into personalized precision medicine that adjusts therapies to the genomic make-up of the child and the specific malignancy. The genomic cancer revolution is only the first step in transforming the SCMCI into a genomic-based hospital applying precision medicine to every child with a serious disease.